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Drugs to be Avoided or Used with Caution in Pregnancy
Drugs Trimester of risk Adverse Effects
1. Cardiovascular system
     (a) Diuretics
3
Reduce plasma volume and placental perfusion and should not be used to treat hypertension in pregnancy.
           Thiazides
3
May cause neonatal thrombocytopenia
    (b) Anti-arrhythmic drugs
             Amiodarone
2,3
Releases iodine with possible risk of neonatal goitre. Use only if no effective alternative.
    (c) Beta-adrenoceptor
         blocking drugs
3
Neonatal hypoglycaemia and bradycardia. The risk is greater in women with severe hypertension.
(d) Antihypertensive drugs Guanethidine

3

Postural hypotension and reduced uteroplacental perfusion. Should not be used to treat hypertension in pregnancy.













 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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