Flemoxin 250mg     Flemoxin 500 mg   Flemoxin Dry Syrup(Paediatric)    Synocef 200 mg    Synocef Dry Syrup

	Synocef®Synocef 100, Synocef 200,Synocef Dry Syrup Cefixime Capsule & CefiximeDry Syrup for Oral Suspension Description Synocef (Cefixime) is a semisynthetic 3rd. generation Cephalosporin antibiotic being structurally similar to Cefdinir, Cefpodoxime proxetil,Ceftibuten. Like Cefdinir, Cefixime contains a vinyl moiety which is partially responsible for the G.I. absorption characteristics and may contribute to Cefixime's potent bacterial activity. Composition Synocef 100 Each hard gelatine capsule contains: Cefixime USP (As Trihydrate) equivalent to Anhydrous Cefixime 100 mg Synocef 200 Each hard gelatine capsule contains: Cefixime USP (As Trihydrate) equivalent to Anhydrous Cefixime 200 mg Synocef Dry Syrup After re-constitution each 5ml of susoension contains: Cefixime USP (As Trihydrate) equivalent to Anhydrous Cefixime 50 mg Actions Synocef (Cefixime) is used orally in adult and pediatric patients for the treatment infections caused by susceptible microbes. Synocef ( Cefixime), like other 3rd. generation Cephalosporins, has an expanded spectrum of activity against gram negative bacteria compared with first and 2nd. generation Cephalosporins. Synocef (Cefixime) is usually bactericidal in action. Like other Cephalosporins, the antibacterial activity of the drug results from inhibition of mucipeptide synthesis in the bacterial cell wall. Betalactum antibiotics bind to several enzymes in the bacterial cytoplasmic membrane (eg. carboxypeptidases, endopeptidase, transpeptidases) that are involved in cell wall synthesis and cell division. Cell death following exposure to beta-lactum antibiotics usually results from lysis, which appears to be mediated by bacterial autolysin such as peptidoglycan hydrolases. The target enzymes of beta-lactum antibiotics have been classified as penicillin binding proteins (PBPA) which appear to vary substantially among bacterial species and this explains the differences in the spectrum of activity of beta-lactum antibiotics. Approximately 30-50% of a single dose is absorbed following oral administration; presence of food generally do not interfere with the extent of absorption, though, rate of absorption of the drug may be affected. Following oral administration of a single 200 or 400 mg dose of Cefixime the time to peek serum concentrations average 3.1 to 4.4 hours and peek serum concentration average 2mcg/ml or 3.7mcg/ml respectively.Cefixime is approximately 65-70% bound to plasma protein, principally albumin, and the elimination half-life, in patients with normal renal function, average 2.4 to 4 hours and may range upto 9 hours in some healthy adults, which is independent of dosage from and is not dose dependent. Indications Uncomplicated u.t.i. in men, women & children, pyelonephritis and other complicated u.t. is in adults;Ac. otisis media, pharyngitis & tonsilitis, acute and chronic bronchitis, mild to moderate pneumonia in adults or children; typhoid fever and other salmonella infections, shigellosis, uncomplicated gonorrhoea. Precautions & Contraindictions Previous hypersensitivity reactions to Cephalosporins, penicillins or other drugs; should be used with caution in individuals with a history of allergy to drugs. Prolonged use along with other antiinfective agents may result in overgrowth of nonsusceptible organisms. Safety and eficacy of Cefuxime in pediatric patients younger than 6 months of age have not been established. Adjustment of dosage may be necessary geriatric patients because of decreased renal function with age. Adverse Reactions Similar to those reported with the Cephalosporins; Cefixime is well tolerated; most frequent adverse effects involve g.i. tract - mild in 20%, moderate in 5-9% and severe in 2-3% of patients; diarrhoea, frequent loose stool, abdominal pain, nausea, vomiting dyspepsia, flatulence may occur in 1-11% of patients. Hypersensitivity reactions have been reported in upto 7% of patients and include rash, urticaria, drug fever, pruritus, arthralgia, erythema-multiforme, facial edema, etc. Thrombocytosis, thrombocytopenia, leukopenia, leukocytosis, eosinophilia have been reported in less than 2% of patients. Transient rise in AST (SGOT) and ALT(SGPT), alkaline phosphates, biliruin have been reported in less than 2% of patients. Transient increase in serum creatinine and BUN may occur in less than 2% of patients. Drug Interactions No clinically important effect is observed when taken with antacids either simultaneously or 2 hours before. Increased prothrombin time with or without bleeding has been reported following concomitant use of anticoagulants (eg. warfarin). Concomitant use of Cefixime & nifedipine increases oral bioavailability of Cefixime; with carbamazepine there may be rise in carbamazepine plasma concentrations. Dosage & Administration Adults : Recommended daily dose is 400 mg; may be given in two divided doses of 200mg 12 hourly. For uncomplicated gonococcal urethritis/ceravicitis single dose of 400mg is suggested. Children : For children > 6 of age: recommended dose is 8mg/kg/day given as a single dose or in two divided doses every 12 hourly. Packing Synocef 100 - Strips of 10 capsules. Synocef 200 - Strips of 4 capsules. Synocef Dry Syrup - Phials 30 ml.