Pyrigesic tablets, syrupand drops for oral administration provide paracetamol, a widely used, non-narcotic, non-salicylate, analgesic and antipyretic of high efficacy. When administered in usual therapeutic dosages, has virtually little side effects

      
Composition

Actions

Analgesic action of Pyrigesic (paracetamol) is believed to be due to inhibition of brain prostaglandin synthetase activity and through a peripheral action by blocking pain impulse generation. The peripheral action is also believed to be due to either inhibition of prostaglandin synthesis or inhibition of actions or synthesis of some other substances responsible for sensitizing pain receptors to chemical or mechanical stimulation. Antipyretic action of Pyrigesic (paracetamol) is believed to be due to its action on the hypothalamic heat-regulating centre producing peripheral vasodilatation and thus resulting in increased blood flow through the skin, sweating and heat loss. This action probably involves inhibition of prostaglandin synthetase activity in the hypothalamus.

 Advantages

• Analgesic and antipyretic effects-qualitatively like those of aspirin in equal dosage
• Suitable for any age and particularly for children
•  Does not cause gastric erosion or bleeding
• Does not produce asthma or wheezing-like side effects

•  Does not interact with anticoagulant therapy

• No effect on platelet functions

• No interference in renal excretion of uric acid

Indications

Pyrigesic (tablets & syrup) is indicated in fever associated with bacterial or viral infections, mild to moderate pain including muscular pain, joint pains, sprains and injuries, wryneck, toothache, headache, earache, neuralgia, post-immunisation reaction, post tonsillectomy pain, menstrual discomfort, discomforts of cold and flu, pharyngitis, laryngitis and tracheobronchitis.

Adverse Reactions

With normal therapeutic doses of Pyrigesic hypersensitivity reactions like erythematous or urticarial skin rashes, mucosal lesions, drug, fever, etc. may occur rarely.
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Precautions

Care should be taken for patients with impaired liver or kidney functions

 Drug Interactions

Co-administration of alcohol and Pyrigesic (paracetamol), at least in high therapeutic doses, may be harmful. With chloramphenicol, half-life of the antibiotic is prolonged which may cause increased toxic effects of the antibiotic, probably due to competitive metabolism that takes place between the two compounds. 

Dosage

Packing

Pyrigesic Tablets : Strips of 10 tablets

Pyrigesic Syrup : Phials 60 ml

Pyrigesic Drops : Phials 15 ml.