|
Description
Locula
is an ophthalmic preparation of sulphacetamide sodium for
the treatment of common inflammatory disorders of the eye
Composition
| Locula 10% |
|
|
| Sodium Sulphacetamide
IP |
10% |
w/v |
| Preservative :
Phenyl Ethyl Alcohol USP |
0.5% |
v/v |
| Locula 20%
|
|
|
| Sodium Sulphacetamide
IP |
20% |
w/v |
| Preservative :
Phenyl Ethyl Alcohol USP |
0.5% |
v/v |
| Locula 30%
|
|
|
| Sodium Sulphacetamide
IP |
30% |
w/v |
| Preservative :
Phenyl Ethyl Alcohol USP |
0.5% |
v/v |
Actions
Sulphacetamide
sodium (Locula) exerts bacteriostatic effect against a wide range
of Gram positive and Gram negative microorganisms. Through
competitive antagonism with
para-aminobenzoic acid it restricts the synthesis of folic
acid which is required for bacterial growth. Excellent result
is observed in conjunctivitis caused by Staphylococcus aureus,
Diplococcus pneumoniae, H. influenzae, Pseudomonas,
Neisseria, Proteus organisms, in blepharoconjunctivitis
due to Staphylococcus aureus, in corneal ulcer due to E.
coli, K. pneumoniae, in trachoma and inclusion bodies.
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Sulphacetamide
sodium (Locula) has remarkable fungistatic activity against Aspergillus,
Candida albicans, Penicillium chrysogenum, Curvalaria lunata
responsible for corneal infections. Sulphacetamide penetrates
readily into aqueous humour and ocular tissues in high concentrations
Indications
Locula
is
useful in the management of conjunctivitis, iritis, corneal
ulcer, ophthalmia neonatorum, blepharitis and other superficial
ocular infections due to susceptible microorganisms.
Contraindications
Hypersensitivity
to sulphonamides.
Adverse Reactions
There
may be local irritation, transient stinging or burning with
30% solution. Sensitivity reactions are rare.
Precautions
Locula
is
incompatible with silver preparations. Non-susceptible organisms
may proliferate with the use of sulphonamide preparations. Sulphonamides
are inactivated by para-aminobenzoic acid present in purulent
exudates. Sensitization and
cross-sensitivity between different sulphonamides may occur.
On development of signs of sensitivity or untoward reactions
use of Locula
should
be discontinued
Dosage
& Administration
2
drops of Locula
to
be instilled into the conjunctival sac every 2 hours initially.
The time interval may be increased as the condition responds.
10% or 20% solutions for mild and chronic infections and 30%
solution for acute and severe cases.
Packing
Locula
10%, Locula 20%, Locula 30%
Dropper
vials 10 ml
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