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Mechanism of action of sodium fluoride in the treatment of elephantoid changes in filariasis is not well understood. However, Florocid therapy has been reported to provide effective clinical results in elephantoid changes due to filariasis with swellings upto three times the normal size and shape. In enormous swelling some subjective improvement has been noted. Florocid therapy in some obstinate cases of chronic funiculitis with small hydrocele, recurrent filarial lymphangitis, filarial chronic pelvic cellulitis has been found to produce satisfactory clinical response. Softening of filarial swellings is also observed in a good number of cases with Florocid therapy, probably, due to some fibrolytic action of sodium fluoride. Improvement has also been noted in cases of chyluria.  

Adverse Reactions

Florocid is generally well-tolerated and no toxic symptoms are reported to occur with scheduled dosage. Some patients may complain of pain for a few days.

Dosage & Administration

Contents of one ampoule of sodium fluoride and one ampoule of procaine hydrochloride are to be drawn into a syringe and injected subcutaneously once a week for 4 weeks. The course may be repeated if necessary, after a rest period of 4 weeks. A preliminary anti-infective treatment facilitates Florocid therapy.

Packing

Ampoules of 4 x 1 ml of each in a carton.