| Description
Enidazol,
Enidazol 500 & Enidazol
1000 are established, highly effective, orally active antiprotozoal
agents
Composition
| Enidazol :
Each film coated tablet contains : |
|
|
| Tinidazole I.P. |
300 |
mg |
| Enidazol
500 : Each film coated tablet contains : |
|
|
| Tinidazole I.P. |
500 |
mg |
| Enidazol
1000 : Each film coated tablet contains : |
|
|
| Tinidazole I.P |
1 |
g |
Actions
Enidazol,
Enidazol 500 & Enidazol 1000
has about four times the antiprotozoal activity of
metronidazole in vivo. It is almost completely absorbed after
oral administration and is widely distributed in body fluids
and tissues.Enidazol,Enidazol
500 & Enidazol 1000 provides
consistently higher serum levels, longer duration of activity
and results in more rapid response in the management of trichomoniasis,
giardiasis and amoebiasis. It is also active against major
problem anaerobeÑBacteroides fragilis. It is resistant to
metabolic degradation.
Indications
Enidazol,
Enidazol 500 & Enidazol 1000 are indicated for the treatment of intestinal amoebiasis,
hepatic amoebiasis, giardiasis , trichomoniasis, anaerobic
infections and ulcerative gingivitis.
Contraindications
Contraindicated
in patients with blood dyscrasia, active organic central nervous
system disease or in patients hypersensitive to tinidazole.
|
Adverse
Reactions
Generally
well-tolerated in most of the cases. Occasionally occurring
side effects include
(a) gastrointestinalÑmetallic
taste in the tongue, nausea, anorexia, vomiting, (b) central
nervous system and neurologicalÑdizziness, vertigo, insomnia,
weakness, (c) haematologicalÑleukopenia (reversible),
(d) dermatologicalÑurticaria, pruritus, flushing, (e) othersÑfever,
proctitis, etc.
Precautions
Mild leukopenia may occur; total and differential counts
should be done before and after treatment, especially if second
course is necessary. Treatment should be discontinued if neurological
signs appear. Alcohol should be avoided during treatment.
It should not be given to nursing mothers and in the first
trimester of pregnancy
Drug Interactions
By
concurrent use with warfarin, the anticoagulant effect may
be significantly enhanced; with disulfiram acute psychoses
and confusion may occur.
Dose
(a)
Intestinal Amoebiasis :
Adult : 600 mg twice daily for 5-10 days or 2 g single
dose for 2-3 days. Children : 50-60 mg/kg
body weight/day in single dose for 3-5 days.
(b)
Amoebic Liver Abscess/Hepatic Amoebiasis :
Adult : 750 mg thrice daily for 5 days or
2 g single dose for 2-3 days. Children :
50-60 mg/kg body weight/day in single dose for 5 days.
(c)
Giardiasis :
Adult : 150 mg twice daily for 7 days or 2 g single dose
once only.
Children : 50 mg/kg body weight as a single dose.
(d)
Trichomoniasis
Adult : 150 mg twice daily for 7 days, or 2 g single
dose once only. Male partner should also be treated.
(e)
Ulcerative Gingivitis :
Adult : 2 g single dose for 1
day
Children : 50-60 mg/Kg body weight as a single
dose.
(f)
Anaerobic Infections :
Adult : 600 mg twice daily on immediate pre-operative
period or 2 g single dose 12 hours before surgery
and 600 mg twice daily for 7 days or 2 g initially
then 500 mg twice daily or 1 g single dose for 5-6 days
in post-operative period.
Packing
Enidazol:
Strips of 10 tablets
Enidazol 500: Strips of 4 tablets
Enidazol 1000: Strips of 2 tablets
|
