|
Description
ASMOTONE
PLUS is a combination of established and effective bronchodilator
Terbutaline, a proven mucolytic agent Bromhexine and a useful
expectorant Guaiphenesin.
Composition
| Each 10 ml contains
: |
|
|
| Bromhexin Hydrochlorid
IP |
8
|
mg |
| Terbutaline
Sulphate IP |
4
|
mg |
| Guaiphenesin
IP |
200
|
mg |
Actions
The
action of Terbutaline is due to activation of adenyl cyclase
that catalyses ATP to CAMP resulting in relaxation of bronchial
smooth muscle. Terbutaline also enhances mucociliary transport
- to help expectoration and thereby control cough. Terbutaline
also is known to cause diminished histamine release and
other chemical mediators from the mast cells and possibly
offers anti-inflammatory effect. Following oral administration
Terbutaline causes flow rate improvement within 30 minutes
with significant clinical improvement of pulmonary function
within 1 - 2 hours with duration of action persisting up to
8 hours. It has long plasma half life of 11 hours compared
to that of 4 hours with Salbutamol.
. Bromhexine is a mucous modifying drug whose action has
been fully documented . It is capable of modulating the
activity of the goblet cells, inducing hydrolytic depolymerization
of the mucoprotein fibers and stimulating the activity of
the ciliated epithelium. This improves the flow properties
of bronchial mucous and eases expectoration which is of value
in the management of bronchitis.
|
Indications
ASMOTONE PLUS
is useful in the treatment of cough associated with chronic
bronchitis, emphysema and bronchial asthma.
Contraindictions
ASMOTONE PLUS is contraindicated
in patients with hypersensitvity to the ingredients, cardiac
patients with associated arrhythmia, ischaemic heart disease
and acute hypertensive patients, patients undergoing anaesthesia,patients
on MAOI's therapy, first trimester of pregnancy, acute porphyria,
thyrotoxicosis.
Adverse
Reactions
ASMOTONE PLUS is generally well
tolerated. Reported side effects aretremor, irritability,
insomnia, anorexia, nausea, vomiting, bradycardia, palpitation,
paradoxical bronchoconstriction.
Precautions
ASMOTONE PLUS should
be used with caution in patients with closed angle glaucoma,
diabetes mellitus, peptic ulcer, liver diseases and during
lactation.
Drug Interactions
Concomitant
use of ASMOTONE PLUS with other sympathomimetic agents may
lead to deleterious cardiovascular effects.
Dosage &
Administration
Adults: 10 ml thrice daily
Children: between 3 - 7 years - 2.5 ml thrice daily
above
7 years - 5 ml thrice daily
Packing
Phials
100 ml.
|
